Mesoblast Chief Executive Silviu Itescu said: We are pleased that Mallinckrodt has chosen to make an investment in Mesoblast. Mallinckrodt has a track record of success in commercializing medicines for immune-mediated diseases and pain management, and we believe that its majorfootprint in hospitals addressing acute care needs canbe leveraged to realize the full commercial and clinical value of our innovative cellular medicines. Steven Romano, M.D., Executive Vice President and Chief Scientific Officer of Mallinckrodt, commented: “This agreement provides Mallinckrodt with a potential opportunity to extend our regenerative medicine pipeline in areas of high unmet patient need. We see Mesoblast as a leader in developing innovative cell-based medicines and look forward to establishing a fruitful partnership.” Mesoblast’s product candidate MPC-06-ID is currently being evaluated in a 360-patient Phase 3 trial as a treatment for moderate/severe CLBP due to disc degeneration in patients who have failed other non-surgical options, including steroid injections and opioids. Data from 24-month follow up of 100 patients participating in a randomized, placebo-controlled Phase 2 trial of MPC-06-ID were presented in August 2016 at the 24th Annual Scientific Meeting of the Spine Intervention Society. Mesoblast’s product candidate MSC-100-IV is currently being evaluated in a 60-patient open label Phase 3 trial as a front-line therapy for children with steroid-refractory acute GVHD. The trial was recently successful in a pre-specified interim futility analysis, and Mesoblast expects to fully read out trial results during 2017. Based on guidance from the United States Food and Drug Administration (FDA), Mesoblast believes that positive data from this Phase 3 trial may be sufficient for filing for accelerated approval of MSC-100-IV in the United States. Mesoblast plans to broaden the use of its therapy in adult patients with high-risk steroid-refractory acute GVHD. About Mallinckrodt Mallinckrodt is a global business that develops, manufactures, markets and distributes specialty pharmaceutical products and therapies, as well as nuclear imaging products. Areas of focus include autoimmune and rare diseases in specialty areas like neurology, rheumatology, nephrology, pulmonology and ophthalmology; immunotherapy and neonatal respiratory critical care therapies; analgesics and hemostasis products; and central nervous system drugs.
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Mat Latos, SP: Remember when Mat Latos was really awesome for four starts? Those were the days, man. 135. Dillon Gee, SP: Pitched his way onto an opening day staff last spring. Probably will need to do the same this one. 136. Eric Sogard, IF: After missing all of last season with shoulder and knee injuries, should pop up in a camp as a non-roster guy with a decent shot at nabbing a utility role. 137. Felix Doubront, SP: Coming off Tommy John surgery and wont be ready until April at earliest. June or July probably a more sensible return date. 138.
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